User Reviews for Zoloft to treat Premenstrual Dysphoric Disorder The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Dosage in Patients with PMDD. The recommended starting ZOLOFT dosage in adult women with PMDD is 50 mg per day. ZOLOFT may be administered either continuously (every day throughout the menstrual cycle) or intermittently (only during the luteal phase of the menstrual cycle, i.e., starting the daily dosage 14 days prior to the anticipated onset. ZOLOFT has helped treat the following conditions in adults: Major Depressive Disorder (MDD), Obsessive-Compulsive Disorder (OCD), Panic Disorder, Posttraumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), and Social Anxiety Disorder. Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder. Zoloft can cause side effect which include, trouble sleeping, panic attacks and anxiety. If you've been diagnosed with PMDD, or have been in a gynecologist's or psychiatrist's office lately, you've probably heard of Sarafem ®, the antidepressant medication that is used as PMDD medication and a drug for severe PMS. My first very amateur video, briefly hitting my issues I deal with daily. I tried Zoloft (which is FDA approved to treat SAD and PMDD), but 50mg didn't do much, and 100mg wouldnt let me sleep more than 2 hours a night for 2 weeks. I've done some research and have come across Paxil also. Zoloft can help in PMS (premenstrual syndrome), freeing you from the emotional and psychological symptoms of PMS. Zoloft, either taken alone or with other mood restoring medication, is particularly helpful for women with severe, type D PMS or PMDD (premenstrual dysphoric disorder). ZOLOFT is a prescription medication for the treatment, in adults, of Major Depressive Disorder (MDD), Obsessive-Compulsive Disorder (OCD), Panic Disorder, Posttraumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), and Social Anxiety Disorder. It is also approved to treat Obsessive Compulsive Disorder (OCD) in children and adolescents aged 6-17 years.